Ethanol → 5-(2-hydroxyethoxy)-5-(1-trityl-1H-imidazol-4-yl)-5,6,7,8-tetrahydronaphthalene-2-carbonitrile

HRID 2155691Notes

Reaction equation

HRID 2155691 reaction equation
[BH4-:1].[C:3](#[N:4])[c:5]1[cH:6][c:7]2[c:12]([cH:13][cH:14]1)[C:11]([O:15][CH2:16][C:17](=[O:18])[O:19][CH2:20][CH3:21])([c:22]1[n:23][cH:24][n:25]([C:27]([c:28]3[cH:29][cH:30][cH:31][cH:32][cH:33]3)([c:34]3[cH:35][cH:36][cH:37][cH:38][cH:39]3)[c:40]3[cH:41][cH:42][cH:43][cH:44][cH:45]3)[cH:26]1)[CH2:10][CH2:9][CH2:8]2.[CH3:46][CH2:47][OH:48].[Na+:2]>>[C:3](#[N:4])[c:5]1[cH:6][c:7]2[c:12]([cH:13][cH:14]1)[C:11]([O:15][CH2:16][CH2:17][OH:18])([c:22]1[n:23][cH:24][n:25]([C:27]([c:28]3[cH:29][cH:30][cH:31][cH:32][cH:33]3)([c:34]3[cH:35][cH:36][cH:37][cH:38][cH:39]3)[c:40]3[cH:41][cH:42][cH:43][cH:44][cH:45]3)[cH:26]1)[CH2:10][CH2:9][CH2:8]2

Participants

5

Reactant 4

HCID 702EthanolHCID 923Sodium ionHCID 28123BorohydrideHCID 86632962ethyl [6-cyano-1-(1-trityl-1H-imidazol-4-yl)-1,2,3,4-tetrahydronaphthalen-1-yloxy]acetate

Product 1

HCID 667821935-(2-hydroxyethoxy)-5-(1-trityl-1H-imidazol-4-yl)-5,6,7,8-tetrahydronaphthalene-2-carbonitrile

Sources & evidence

ORD record
ord-a2d9c4eafd6a4a4b83a1b61336536e7f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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