HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → 2-[(3-Bromophenyl)methoxy]oxane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | 3,4-dihydro-2H-pyran | HCID 8080 | — |
| Reactant | 3-Bromobenzyl alcohol | HCID 85141 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-[(3-Bromophenyl)methoxy]oxane | HCID 15282064 | — |
Reaction Steps
A solution of 3-bromobenzyl alcohol (84.9 g; Aldrich), 3,4-dihydro-2H-pyran (44 g) and anhydrous p-toluene sulfonic acid (1 g) in CH2Cl2 (800 mL) was stirred at 5° C. for 1 hr. then at r.t. overnight. The mixture was concentrated and the residue chromatographed (5% EtOAc/hexane) to afford the title compound as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05424320 |
| Source dataset | uspto-grants-1995_06 |
| ORD ID | ord-2db09be680da427fb5198d935bceca3f |
| Source note | uspto-grants-1995_06 |