Formic Acid → 1-Cyclopropyl-8-(3,4-dimethyl-1-piperazinyl)-7-fluoro-4-oxo-1,4-dihydro-benzo[b][1,8]naphthyridine-3-carboxylic acid

HRID 2156219Notes

Reaction equation

HRID 2156219 reaction equation
[CH2:30]=[O:31].[CH:1]1([n:4]2[cH:5][c:6]([C:27](=[O:28])[OH:29])[c:7](=[O:26])[c:8]3[cH:9][c:10]4[c:11]([n:12][c:13]23)[cH:14][c:15]([N:19]2[CH2:20][CH:21]([CH3:25])[NH:22][CH2:23][CH2:24]2)[c:16]([F:18])[cH:17]4)[CH2:2][CH2:3]1.[CH:32]([OH:33])=[O:34]>>[CH:1]1([n:4]2[cH:5][c:6]([C:27](=[O:28])[OH:29])[c:7](=[O:26])[c:8]3[cH:9][c:10]4[c:11]([n:12][c:13]23)[cH:14][c:15]([N:19]2[CH2:20][CH:21]([CH3:25])[N:22]([CH3:30])[CH2:23][CH2:24]2)[c:16]([F:18])[cH:17]4)[CH2:2][CH2:3]1

Participants

4

Reactant 3

HCID 284Formic AcidHCID 712FormaldehydeHCID 147005751-Cyclopropyl-7-fluoro-8-(3-methyl-1-piperazinyl)-4-oxo-1,4-dihydro-benzo[b][1,8]naphthyridine-3-carboxylic acid

Product 1

HCID 147005811-Cyclopropyl-8-(3,4-dimethyl-1-piperazinyl)-7-fluoro-4-oxo-1,4-dihydro-benzo[b][1,8]naphthyridine-3-carboxylic acid

Sources & evidence

ORD record
ord-c3fb624c71d54deba8f43f5badc74ffd
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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