Pyridine → tert-Butyl 4-(trifluoromethyl)-3',6'-dihydro-2,4'-bipyridine-1'(2'H)-carboxylate

HRID 2156307Notes

Reaction equation

HRID 2156307 reaction equation
[OH:1][C:2]1([c:15]2[n:16][cH:17][cH:18][c:19]([C:21]([F:22])([F:23])[F:24])[cH:20]2)[CH2:3][CH2:4][N:5]([C:8](=[O:9])[O:10][C:11]([CH3:12])([CH3:13])[CH3:14])[CH2:6][CH2:7]1.[S:25]([Cl:26])([Cl:27])=[O:28].[cH:29]1[cH:30][cH:31][n:32][cH:33][cH:34]1>>[C:2]1([c:15]2[n:16][cH:17][cH:18][c:19]([C:21]([F:22])([F:23])[F:24])[cH:20]2)=[CH:3][CH2:4][N:5]([C:8](=[O:9])[O:10][C:11]([CH3:12])([CH3:13])[CH3:14])[CH2:6][CH2:7]1

Participants

4

Reactant 3

HCID 1049PyridineHCID 24386Thionyl ChlorideHCID 59833581tert-Butyl4-hydroxy-4-[4-(trifluoromethyl)pyridin-2-yl]piperidine-1-carboxylate

Product 1

HCID 59833541tert-Butyl 4-(trifluoromethyl)-3',6'-dihydro-2,4'-bipyridine-1'(2'H)-carboxylate

Sources & evidence

ORD record
ord-75c93d43851644bdb3b855e2c05f4353
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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