Sulfuric Acid → HCID 25096725, compound

HRID 215676Notes

Reaction equation

HRID 215676 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([OH:23])=[C:7]([C:9](=[O:22])[CH2:10][C:11]([C:13]2[CH:18]=[CH:17][C:16]([N+:19]([O-:21])=[O:20])=[CH:15][CH:14]=2)=O)[CH:8]=1.S(=O)(=O)(O)O>C(O)(=O)C>[CH3:1][O:2][C:3]1[CH:8]=[C:7]2[C:6](=[CH:5][CH:4]=1)[O:23][C:11]([C:13]1[CH:14]=[CH:15][C:16]([N+:19]([O-:21])=[O:20])=[CH:17][CH:18]=1)=[CH:10][C:9]2=[O:22]

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 42636587HCID 42636587, compound

Product 1

HCID 25096725HCID 25096725, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixed solution consisting of compound 22 (2.92 g, 9.26 mmol), concentrated sulfuric acid (1 ml), and acetic acid (50 ml) was heated to reflux for 1 hour. The temperature of the resultant was returned to room temperature, and ice pieces were then added to the reaction solution. The precipitated crystal was collected by filtration, so as to obtain a product of interest, 6-methoxy-4′-nitroflavone (compound 23). Yield: 2.31 g (yield constant: 84.1%)

Workup

  1. temperaturewas heated
  2. temperatureto reflux for 1 hour
  3. customwas returned to room temperature
  4. additionice pieces were then added to the reaction solution
  5. filtrationThe precipitated crystal was collected by filtration

Sources & evidence

ORD record
ord-ec8093e8f99844c7b25b43ef7239b80d
Source dataset
uspto-grants-2012_06
Patent number
US08192717B2

Reaction notes

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