Formaldehyde → HCID 25096969, compound

Participants

Reaction Steps

Sodium cyanoborohydride (891 mg, 14.1 mmol) was slowly added to an acetic acid solution (30 ml) that contained compound 24 (630 mg, 2.36 mmol) and paraformaldehyde (707 mg, 23.6 mmol), while stirring. The obtained mixture was stirred at room temperature for 3 hours. After completion of the reaction, 50 ml of a 1 N sodium hydroxide aqueous solution was added to the reaction solution, and the obtained mixture was then extracted with 50 ml (25 ml×2) of chloroform. The extract was dried over anhydrous sodium sulfate, and the solvent was then distilled away under reduced pressure, so as to obtain a product of interest, 6-methoxy-4′-dimethylaminoflavone (compound 25) in the form of a yellow crystal. Yield: 450 mg (yield constant: 64.6%) 1H NMR (300 MHz, CDCl3) δ8.31 (s, 1H), 7.69-7.75 (m, 3H), 7.39 (d, J=8.7 Hz, 1H), 6.62-6.66 (m, 3H), 4.18 (s, 1H). 2.91 (s, 3H).

Provenance & Evidence