Thiomorpholine 1,1-dioxide → 2-[4-[2-[(1,1-Dioxo-1,4-thiazinan-4-yl)methyl]-4-thiophen-2-ylsulfonylpiperazin-1-yl]phenyl]-1,1,1-trifluoropropan-2-ol

HRID 2156998Notes

Reaction equation

HRID 2156998 reaction equation
[CH3:1][S:2]([O:3][CH2:6][CH:7]1[N:8]([c:21]2[cH:22][cH:23][c:24]([C:27]([C:28]([F:29])([F:30])[F:31])([CH3:32])[OH:33])[cH:25][cH:26]2)[CH2:9][CH2:10][N:11]([S:13](=[O:14])(=[O:15])[c:16]2[s:17][cH:18][cH:19][cH:20]2)[CH2:12]1)(=[O:4])=[O:5].[S:34]1(=[O:40])(=[O:41])[CH2:35][CH2:36][NH:37][CH2:38][CH2:39]1>>[CH2:6]([CH:7]1[N:8]([c:21]2[cH:22][cH:23][c:24]([C:27]([C:28]([F:29])([F:30])[F:31])([CH3:32])[OH:33])[cH:25][cH:26]2)[CH2:9][CH2:10][N:11]([S:13](=[O:14])(=[O:15])[c:16]2[s:17][cH:18][cH:19][cH:20]2)[CH2:12]1)[N:37]1[CH2:36][CH2:35][S:34](=[O:40])(=[O:41])[CH2:39][CH2:38]1

Participants

3

Reactant 2

HCID 6484228Thiomorpholine 1,1-dioxideHCID 86670324(4-(2-Thiophenylsulfonyl)-1-(4-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)phenyl)-2-piperazinyl)methyl methanesulfonate

Product 1

HCID 764622972-[4-[2-[(1,1-Dioxo-1,4-thiazinan-4-yl)methyl]-4-thiophen-2-ylsulfonylpiperazin-1-yl]phenyl]-1,1,1-trifluoropropan-2-ol

Sources & evidence

ORD record
ord-40c0ac4c95cd443cbece955d61e810da
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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