4-(2,6-Difluoro-phenyl)-1,3-dihydro-indol-2-one → 2-[4-(2,6-Difluoro-phenyl)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl]-3-methyl-5-(2-piperidin-1-yl-ethyl)-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one

HRID 2157188Notes

Reaction equation

HRID 2157188 reaction equation
[CH3:1][c:2]1[c:3]([CH:20]=[O:21])[nH:4][c:5]2[c:6]1[C:7](=[O:19])[N:8]([CH2:11][CH2:12][N:13]1[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]1)[CH2:9][CH2:10]2.[F:22][c:23]1[c:24](-[c:30]2[c:31]3[c:35]([cH:36][cH:37][cH:38]2)[NH:34][C:33](=[O:39])[CH2:32]3)[c:25]([F:29])[cH:26][cH:27][cH:28]1>>[CH3:1][c:2]1[c:3]([CH:20]=[C:32]2[c:31]3[c:30](-[c:24]4[c:23]([F:22])[cH:28][cH:27][cH:26][c:25]4[F:29])[cH:38][cH:37][cH:36][c:35]3[NH:34][C:33]2=[O:39])[nH:4][c:5]2[c:6]1[C:7](=[O:19])[N:8]([CH2:11][CH2:12][N:13]1[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]1)[CH2:9][CH2:10]2

Participants

3

Reactant 2

HCID 225617464-(2,6-Difluoro-phenyl)-1,3-dihydro-indol-2-oneHCID 866376773-methyl-4-oxo-5-(2-piperidin-1-yl-ethyl)-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridine-2-carbaldehyde

Product 1

HCID 666079302-[4-(2,6-Difluoro-phenyl)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl]-3-methyl-5-(2-piperidin-1-yl-ethyl)-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one

Sources & evidence

ORD record
ord-7ab7b483d2804a55afa660d8d6895239
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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