Bromide ion → 2-Chloro-4-(2-[1,3]dioxan-2-yl-ethyl)-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidine

HRID 2157280Notes

Reaction equation

HRID 2157280 reaction equation
[Br-:21].[CH2:1]([c:2]1[c:3]2[n:4][c:5](-[c:6]3[cH:7][cH:8][c:9]([F:10])[cH:11][cH:12]3)[cH:13][cH:14][c:15]2[n:16][c:17]([NH2:18])[n:19]1)[CH3:20].[Cl:31][c:32]1[n:33][c:34]([Cl:49])[c:35]2[c:36]([n:37]1)[cH:38][cH:39][c:40](-[c:42]1[cH:43][cH:44][c:45]([F:48])[cH:46][cH:47]1)[n:41]2.[O:22]1[CH:23]([CH2:28][CH2:29][Mg+:30])[O:24][CH2:25][CH2:26][CH2:27]1>>[O:22]1[CH:23]([CH2:28][CH2:29][c:34]2[n:33][c:32]([Cl:31])[n:37][c:36]3[c:35]2[n:41][c:40](-[c:42]2[cH:43][cH:44][c:45]([F:48])[cH:46][cH:47]2)[cH:39][cH:38]3)[O:24][CH2:25][CH2:26][CH2:27]1

Participants

5

Reactant 4

HCID 259Bromide ionHCID 249638764-Ethyl-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidin-2-amineHCID 596478432,4-Dichloro-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidineHCID 178507056HCID 178507056, compound

Product 1

HCID 579067552-Chloro-4-(2-[1,3]dioxan-2-yl-ethyl)-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidine

Sources & evidence

ORD record
ord-e2692a3804784abda3db97d08b972e19
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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