HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 2,3-Dihydro-6-hydroxy-4,7-dimethoxybenzofuran-5-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 5-Benzofurancarboxylic acid, 6-hydroxy-4,7-dimethoxy- | HCID 12211461 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2,3-Dihydro-6-hydroxy-4,7-dimethoxybenzofuran-5-carboxylic acid | HCID 19933221 | 73.4% |
Reaction Steps
5 g of 6-hydroxy-4,7-dimethoxybenzofuran-5-carboxylic acid in 75 ml of ethanol/25 ml of H2O/0.8 g of NaOH are hydrogenated in the presence of 1 g of Pd/C (10%) under atmospheric pressure and at 50° C. until uptake of hydrogen is complete. The mixture is filtered, the ethanol is removed by distillation, the aqueous phase is acidified, and the solid is filtered off with suction. 3.7 g of product are obtained and reacted further without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05424330 |
| Source dataset | uspto-grants-1995_06 |
| ORD ID | ord-d4e611dc44724a6b8160f1cb54fb0f2f |
| Source note | uspto-grants-1995_06 |