5-(Aminomethyl)-2-(trifluoromethyl)pyridine → 5-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-3-methyl-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)thiophene-2-carboxamide

HRID 2157941Notes

Reaction equation

HRID 2157941 reaction equation
[CH3:1][c:2]1[cH:3][c:4]([N:5]2[CH2:6][CH2:7][N:8]([CH2:9][CH2:10][O:11][c:12]3[cH:13][cH:14][cH:15][cH:16][cH:17]3)[C:18]2=[O:19])[s:20][c:21]1[C:22]([OH:23])=[O:24].[F:25][c:26]1[cH:27][cH:28][c:29]([CH2:30][N:31]2[C:32](=[O:45])[N:33]([c:36]3[cH:37][c:38]([CH3:44])[c:39]([C:41](=[O:42])[OH:43])[s:40]3)[CH2:34][CH2:35]2)[cH:46][cH:47]1.[F:48][C:49]([c:50]1[cH:51][cH:52][c:53]([CH2:56][NH2:57])[cH:54][n:55]1)([F:58])[F:59]>>[F:25][c:26]1[cH:27][cH:28][c:29]([CH2:30][N:31]2[C:32](=[O:45])[N:33]([c:36]3[cH:37][c:38]([CH3:44])[c:39]([C:41](=[O:42])[NH:57][CH2:56][c:53]4[cH:52][cH:51][c:50]([C:49]([F:48])([F:58])[F:59])[n:55][cH:54]4)[s:40]3)[CH2:34][CH2:35]2)[cH:46][cH:47]1

Participants

4

Reactant 3

HCID 27377185-(Aminomethyl)-2-(trifluoromethyl)pyridineHCID 580314563-Methyl-5-(2-oxo-3-(2-phenoxyethyl)imidazolidin-1-yl)thiophene-2-carboxylic acidHCID 580314655-(3-(4-Fluorobenzyl)-2-oxoimidazolidin-1-yl)-3-methylthiophene-2-carboxylic acid

Product 1

HCID 250966935-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-3-methyl-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)thiophene-2-carboxamide

Sources & evidence

ORD record
ord-ad2e32866f724ad8ae234d6008c27ed7
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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