Toluene → 5-{1-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-1H-imidazol-4-yl}-pyridine-3-sulfonic acid amide

HRID 2157967Notes

Reaction equation

HRID 2157967 reaction equation
[Br:39][c:40]1[cH:41][c:42]([S:46](=[O:47])(=[O:48])[NH2:49])[cH:43][n:44][cH:45]1.[CH2:1]([Sn:2]([CH2:3][CH2:4][CH2:5][CH3:31])([c:6]1[n:7][cH:8][n:9](-[c:11]2[n:12][c:13](-[c:21]3[cH:22][cH:23][c:24]([C:27]([F:28])([F:29])[F:30])[cH:25][cH:26]3)[cH:14][c:15]([C:17]([F:18])([F:19])[F:20])[cH:16]2)[cH:10]1)[CH2:32][CH2:33][CH2:34][CH3:35])[CH2:36][CH2:37][CH3:38].[CH3:50][CH2:51][CH2:52][CH2:53][CH2:54][CH2:55][CH3:56].[CH3:57][c:58]1[cH:59][cH:60][cH:61][cH:62][cH:63]1>>[c:6]1(-[c:40]2[cH:41][c:42]([S:46](=[O:47])(=[O:48])[NH2:49])[cH:43][n:44][cH:45]2)[n:7][cH:8][n:9](-[c:11]2[n:12][c:13](-[c:21]3[cH:22][cH:23][c:24]([C:27]([F:28])([F:29])[F:30])[cH:25][cH:26]3)[cH:14][c:15]([C:17]([F:18])([F:19])[F:20])[cH:16]2)[cH:10]1

Participants

5

Reactant 4

HCID 1140TolueneHCID 8900HeptaneHCID 126842585-Bromopyridine-3-sulfonamideHCID 574688332-(4-Tributylstannanyl-imidazol-1-yl)-4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyridine

Product 1

HCID 574690325-{1-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-1H-imidazol-4-yl}-pyridine-3-sulfonic acid amide

Sources & evidence

ORD record
ord-55c97824006847f9942514b45f3a229f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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