2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → 5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-(1-methyl-1H-1,2,3-triazol-4-yl)pyridin-2-yl]amino}thiophene-3-carboxamide

HRID 2158172Notes

Reaction equation

HRID 2158172 reaction equation
[Br:1][c:2]1[n:3][c:4](-[c:8]2[n:9][n:10][n:11]([CH3:13])[cH:12]2)[cH:5][cH:6][cH:7]1.[NH2:14][c:15]1[s:16][c:17](-[c:23]2[c:24]([F:34])[cH:25][c:26]([C:30]([CH3:31])([CH3:32])[OH:33])[cH:27][c:28]2[F:29])[cH:18][c:19]1[C:20](=[O:21])[NH2:22]>>[c:2]1([NH:14][c:15]2[s:16][c:17](-[c:23]3[c:24]([F:34])[cH:25][c:26]([C:30]([CH3:31])([CH3:32])[OH:33])[cH:27][c:28]3[F:29])[cH:18][c:19]2[C:20](=[O:21])[NH2:22])[n:3][c:4](-[c:8]2[n:9][n:10][n:11]([CH3:13])[cH:12]2)[cH:5][cH:6][cH:7]1

Participants

3

Reactant 2

HCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 595259902-Bromo-6-(1-methyl-1H-1,2,3-triazol-4-yl)pyridine

Product 1

HCID 595256565-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-(1-methyl-1H-1,2,3-triazol-4-yl)pyridin-2-yl]amino}thiophene-3-carboxamide

Sources & evidence

ORD record
ord-0fdc725d83084a51b7e74ee11222b40f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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