Acetic Acid → HCID 67297269, compound

Participants

Reaction Steps

To a mixture of 4-(3-methyl-5-nitro-pyridin-2-yloxy)-benzoic acid methyl ester (0.43 g, 1.49 mmol) from the previous step and zinc dust (0.932 g, 14.2 mmol) in methanol (15 ml) was added dropwise acetic acid (0.32 ml, 5.12 mmol). The mixture was stirred for 1 h at room temperature and filtered through a thin silica pad to remove inorganics. The filtrate was concentrated at reduced pressure to dryness to provide methyl 4-(5-amino-3-methylpyridin-2-yloxy)benzoate (0.346 g, 90% yield).

Provenance & Evidence