1H-Indole-2-carboxylic acid, 1-methyl-5-(phenylmethoxy)-, ethyl ester → Ethyl 3-bromo-1-methyl-5-(phenylmethoxy)-1H-indole-2-carboxylate

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Reaction Steps

A solution of ethyl 1-methyl-5-(phenylmethoxy)-1H-indole-2-carboxylate (60.9 g, 197 mmol; Monge Vega A, et al., An. Ouim. 1976;72:267) in 550 mL of pyridine is cooled in ice and treated dropwise with a solution of pyridinium bromide perbromide (67.0 g, 209 mmol) in 200 mL of pyridine. The cooling bath is removed, and the mixture is stirred for 16 hours, then added to 4.0 L of cold water. The precipitated solid is filtered, washed with water, and recrystallized from ethyl acetate-hexane to give 58.4 g (76%) of product; mp 125-127° C.

Provenance & Evidence