Tert-butyl propionylcarbamate → [(1S,4R)-4-(2,6-Dichloro-purin-9-yl)-cyclopent-2-enyl]-propionyl-carbamic acid tert-butyl ester

HRID 215849Notes

Reaction equation

HRID 215849 reaction equation
[C:1]([N:8]([C:25]([O:27]C(C)(C)C)=O)[C@H:9]1[CH2:13][C@@H:12]([N:14]2[CH:22]=[N:21][C:20]3[C:15]2=[N:16][C:17]([Cl:24])=[N:18][C:19]=3[Cl:23])[CH:11]=[CH:10]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[C:32](OC(=O)NC(=O)CC)(C)(C)[CH3:33]>>[C:4]([O:3][C:1](=[O:2])[N:8]([C@H:9]1[CH2:13][C@@H:12]([N:14]2[CH:22]=[N:21][C:20]3[C:15]2=[N:16][C:17]([Cl:24])=[N:18][C:19]=3[Cl:23])[CH:11]=[CH:10]1)[C:25](=[O:27])[CH2:32][CH3:33])([CH3:5])([CH3:7])[CH3:6]

Participants

3

Reactant 2

HCID 14221819Tert-butyl propionylcarbamateHCID 58025018Di-Boc-[(1S,4R)-4-(2,6-dichloro-purin-9-yl)-cyclopent-2-enyl]-amine

Product 1

HCID 86622633[(1S,4R)-4-(2,6-Dichloro-purin-9-yl)-cyclopent-2-enyl]-propionyl-carbamic acid tert-butyl ester

Procedure

The title compound is prepared analogously to di-Boc-[(1S,4R)-4-(2,6-dichloro-purin-9-yl)-cyclopent-2-enyl]-amine by replacing di-t-butyliminodicarboxylate with propionyl-carbamic acid tert-butyl ester.

Sources & evidence

ORD record
ord-e2be6bb14bb140c1b36e39b175a15095
Source dataset
uspto-grants-2012_06
Patent number
US08193164B2

Reaction notes

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