HRID215854

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID12933274

4-Ethyl-1H-pyrazole

C5H8N2

结构：CCc1nnn(C2CC(n3cnc4c(NCC(c5ccccc5)c5ccccc5)nc(Cl)nc43)C(O)C2O)n1

HCID86643669

未命名化合物

PRODUCTS

生成物

结构：CCc1cnn([C@H]2C[C@@H](n3cnc4c(NCC(c5ccccc5)c5ccccc5)nc(Cl)nc43)[C@H](O)[C@@H]2O)c1

HCID86622836

未命名化合物

PROCEDURE

实验过程

The title compound is prepared analogously to 1R,2S,3R,5S)-3-[2-chloro-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-5-(5-ethyl-tetrazol-2-yl)-cyclopentane-1,2-diol (Intermediate EA) by replacing 5-ethyltetrazole with 4-ethyl-1H-pyrazole. MS (ES+) m/e 544.23 (MH+)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b49bd5987a02491d9635a121d6a92fb3
来源数据集: uspto-grants-2012_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08193164B2
来源说明: uspto-grants-2012_06

反应 SMILES

[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH:11]2[CH2:15][CH:14]([N:16]3N=N[C:18]([CH2:21][CH3:22])=[N:17]3)[CH:13]([OH:23])[CH:12]2[OH:24])=[C:4]([NH:25][CH2:26][CH:27]([C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[N:3]=1.[CH2:40](C1C=NNC=1)[CH3:41]>>[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[C@@H:11]2[CH2:15][C@H:14]([N:16]3[CH:22]=[C:21]([CH2:40][CH3:41])[CH:18]=[N:17]3)[C@@H:13]([OH:23])[C@H:12]2[OH:24])=[C:4]([NH:25][CH2:26][CH:27]([C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=2)[C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[N:3]=1