HuagongsheHuagongshe Chemistry Print Report · For research reference only
2h-1,2,3-Triazol-4-Ylmethanol → (1R,2S,3R,5S)-3-(2,6-Dichloro-purin-9-yl)-5-(4-hydroxymethyl-[1,2,3]triazol-2-yl)-cyclopentane-1,2-diol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2h-1,2,3-Triazol-4-Ylmethanol | HCID 253878 | — |
| Reactant | (1S,2R,3S,5R)-3-(di-tert-butoxycarbonylamino)-5-(2,6-dichloro-purin-9-yl)-cyclopentane-1,2-diol | HCID 57777515 | — |
| Product | (1R,2S,3R,5S)-3-(2,6-Dichloro-purin-9-yl)-5-(4-hydroxymethyl-[1,2,3]triazol-2-yl)-cyclopentane-1,2-diol | HCID 59418979 | — |
Reaction Steps
This compound is prepared analogously to (1S,2R,3S,5R)-3-(di-Boc-amino)-5-(2,6-dichloro-purin-9-yl)-cyclopentane-1,2-diol (Step AA4) by replacing di-t-butyliminodicarboxylate (Step AA3) with (2H-[1,2,3]triazol-4-yl)-methanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08193164B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-ebf83a312a224553a02ed32f0c64f8ac |
| Source note | uspto-grants-2012_06 |