Methanol → Olopatadine Impurity 54

HRID 2158608Notes

Reaction equation

HRID 2158608 reaction equation
[CH3:1][N:2]([CH2:3][CH2:4][CH:5]=[C:6]1[c:7]2[c:8]([cH:17][cH:18][c:19]([C:21](=[O:22])[O:23][CH3:24])[cH:20]2)[O:9][CH2:10][c:11]2[c:12]1[cH:13][cH:14][cH:15][cH:16]2)[CH3:25].[CH3:26][OH:27].[Na+:29].[OH-:28].[OH2:30]>>[CH3:1][N:2]([CH2:3][CH2:4][CH:5]=[C:6]1[c:7]2[c:8]([cH:17][cH:18][c:19]([C:21](=[O:22])[OH:23])[cH:20]2)[O:9][CH2:10][c:11]2[c:12]1[cH:13][cH:14][cH:15][cH:16]2)[CH3:25]

Participants

6

Reactant 5

HCID 887MethanolHCID 923Sodium ionHCID 961HydroxideHCID 962WaterHCID 53998201Methyl 11-(3-dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepin-2-carboxylate

Product 1

HCID 53645991Olopatadine Impurity 54

Sources & evidence

ORD record
ord-64f8ee5566ea4746bc96161832329c1e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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