HuagongsheHuagongshe Chemistry Print Report · For research reference only
[(R)-1-(4-tert-Butoxycarbonylamino-cyclohexylcarbamoyl)-pyrrolidin-3-yl]-carbamic acid tert-butyl ester → (R)-3-Amino-pyrrolidine-1-carboxylic acid (4-amino-cyclohexyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | [(R)-1-(4-tert-Butoxycarbonylamino-cyclohexylcarbamoyl)-pyrrolidin-3-yl]-carbamic acid tert-butyl ester | HCID 67023870 | — |
| Reactant | N,N'-bis-(4-amino-cyclohexyl)-6-chloro-[1,3,5]triazine-2,4-diamine | HCID 86643674 | — |
| Product | (R)-3-Amino-pyrrolidine-1-carboxylic acid (4-amino-cyclohexyl)-amide | HCID 67022910 | — |
Reaction Steps
(R)-3-Amino-pyrrolidine-1-carboxylic acid (4-amino-cyclohexyl)-amide is prepared analogously to N,N′-bis-(4-amino-cyclohexyl)-6-chloro-[1,3,5]triazine-2,4-diamine (Intermediate IA) by replacing Intermediate IA1 with [(R)-1-(4-tert-butoxycarbonylamino-cyclohexylcarbamoyl)-pyrrolidin-3-yl]-carbamic acid tert-butyl ester (IF2)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08193164B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-b787c2af05bd408cbd6ae8ff124111f6 |
| Source note | uspto-grants-2012_06 |