4-(N-Boc-amino)piperidine → 4-Amino-piperidine-1-carboxylic acid (4-amino-cyclohexyl)-amide

HRID 215867Notes

Reaction equation

HRID 215867 reaction equation
[NH2:1][CH:2]1[CH2:7][CH2:6][CH:5]([NH:8][C:9]([N:11]2[CH2:15][CH2:14][C@@H:13]([NH2:16])[CH2:12]2)=[O:10])[CH2:4][CH2:3]1.[C:17](OC(=O)NC1CCNCC1)(C)(C)C>>[NH2:1][CH:2]1[CH2:3][CH2:4][CH:5]([NH:8][C:9]([N:11]2[CH2:15][CH2:14][CH:13]([NH2:16])[CH2:12][CH2:17]2)=[O:10])[CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 7238334-(N-Boc-amino)piperidineHCID 67022910(R)-3-Amino-pyrrolidine-1-carboxylic acid (4-amino-cyclohexyl)-amide

Product 1

HCID 670230114-Amino-piperidine-1-carboxylic acid (4-amino-cyclohexyl)-amide

Procedure

4-Amino-piperidine-1-carboxylic acid (4-amino-cyclohexyl)-amide is prepared analogously to (R)-3-amino-pyrrolidine-1-carboxylic acid (4-amino-cyclohexyl)-amide (Intermediate IF) by replacing (R)-pyrrolidin-3-yl-carbamic acid tert-butyl ester with piperidin-4-yl-carbamic acid tert-butyl ester.

Sources & evidence

ORD record
ord-710b50b4c1684226aae91e7c96f2a85e
Source dataset
uspto-grants-2012_06
Patent number
US08193164B2

Reaction notes

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