HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-(+)-1-Boc-3-aminopyrrolidine → 1-(4-Amino-cyclohexyl)-3-(R)-pyrrolidin-3-yl-urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-(+)-1-Boc-3-aminopyrrolidine | HCID 854070 | — |
| Reactant | (R)-3-Amino-pyrrolidine-1-carboxylic acid (4-amino-cyclohexyl)-amide | HCID 67022910 | — |
| Product | 1-(4-Amino-cyclohexyl)-3-(R)-pyrrolidin-3-yl-urea | HCID 58025002 | — |
Reaction Steps
1-(4-Amino-cyclohexyl)-3-(R)-pyrrolidin-3-yl-urea is prepared analogously to (R)-3-amino-pyrrolidine-1-carboxylic acid (4-amino-cyclohexyl)-amide (Intermediate IF) by replacing (R)-pyrrolidin-3-yl-carbamic acid tert-butyl ester with (R)-3-amino-pyrrolidine-1-carboxylic acid tert-butyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08193164B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-1790c794075d463aa5754fe00baf2dc0 |
| Source note | uspto-grants-2012_06 |