(R)-(+)-1-Boc-3-aminopyrrolidine → (R)-3-Amino-pyrrolidine-1-carboxylic acid (R)-pyrrolidin-3-ylamide

HRID 215870Notes

Reaction equation

HRID 215870 reaction equation
NC1[CH2:7][CH2:6][CH:5]([NH:8][C:9]([N:11]2[CH2:15][CH2:14][C@@H:13]([NH2:16])[CH2:12]2)=[O:10])[CH2:4]C1.C(OC([N:24]1CC[C@@H](N)C1)=O)(C)(C)C>>[NH:24]1[CH2:7][CH2:6][C@@H:5]([NH:8][C:9]([N:11]2[CH2:15][CH2:14][C@@H:13]([NH2:16])[CH2:12]2)=[O:10])[CH2:4]1

Participants

3

Reactant 2

HCID 854070(R)-(+)-1-Boc-3-aminopyrrolidineHCID 67022910(R)-3-Amino-pyrrolidine-1-carboxylic acid (4-amino-cyclohexyl)-amide

Product 1

HCID 58025012(R)-3-Amino-pyrrolidine-1-carboxylic acid (R)-pyrrolidin-3-ylamide

Procedure

(R)-3-Amino-pyrrolidine-1-carboxylic acid (R)-pyrrolidin-3-ylamide is prepared analogously to (R)-3-amino-pyrrolidine-1-carboxylic acid (4-amino-cyclohexyl)-amide (Intermediate IF) by replacing (4-amino-cyclohexyl)-carbamic acid tert-butyl ester with (R)-3-amino-pyrrolidine-1-carboxylic acid tert-butyl ester.

Sources & evidence

ORD record
ord-983da489732248f1890945b0fd8bd093
Source dataset
uspto-grants-2012_06
Patent number
US08193164B2

Reaction notes

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