HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 215874Generated: October 30, 2026
(3R)-1-benzylpyrrolidin-3-amine → [(R)-1-((R)-1-Benzyl-pyrrolidin-3-ylcarbamoyl)-pyrrolidin-3-yl]-carbamic acid tert-butyl ester
https://huagongshe.com/reaction/215874
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | (3R)-1-benzylpyrrolidin-3-amine | HCID 1519354 | — |
| Reactant | (R)-3-tert-Butoxycarbonylamino-pyrrolidine-1-carboxylic acid phenyl ester | HCID 67022933 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | [(R)-1-((R)-1-Benzyl-pyrrolidin-3-ylcarbamoyl)-pyrrolidin-3-yl]-carbamic acid tert-butyl ester | HCID 67022985 | — |
Reaction Steps
(R)-3-tert-Butoxycarbonylamino-pyrrolidine-1-carboxylic acid phenyl ester (1 eq.) and (R)-1-benzyl-pyrrolidin-3-ylamine (1 eq.) are dissolved in NMP and heated at 100° C. for 1 hour.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08193164B2 |
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| Source dataset | uspto-grants-2012_06 |
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| ORD ID | ord-c75981ccb1d34b3bbf45d15a6bbfcbdc |
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| Source note | uspto-grants-2012_06 |
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