反应详情

温度

0 °C

9-((1R,4S)-4-Hydroxy-cyclopent-2-enyl)-6-((S)-1-hydroxymethyl-2-phenyl-ethylamino)-9H-purine-2-carboxylic acid methyl ester (Intermediate WA) is dissolved in THF (dry). Pyridine is added and the reaction mixture is cooled to 0° C. Ethyl chloroformate is added dropwise keeping the temperature below 10° C. The reaction mixture is warmed to RT and stirred for 2 hours. The reaction mixture is reduced in vacuo and portioned between EtOAc and (1 M) HCl(aq). The organics are washed with water, brine, dried (MgSO4) and reduced in vacuo. The resulting residue is columned to give the title compound.

1. customthe temperature below 10° C
2. temperatureThe reaction mixture is warmed to RT
3. washThe organics are washed with water, brine
4. dry with materialdried (MgSO4)