Benzyloxyacetyl chloride → 2-Benzyloxy-N-{(1S,2R,3S,4R)-4-[2-chloro-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl}-acetamide

Participants

Role	Name	HCID	Charge
Reactant	Benzyloxyacetyl chloride	HCID 177085	—
Reactant	N-[(1S,2R,3S,4R)-4-[2-Chloro-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl]-propionamide	HCID 86622630	—
Product	2-Benzyloxy-N-{(1S,2R,3S,4R)-4-[2-chloro-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl}-acetamide	HCID 42632124	—

Reaction Steps

The title compound is prepared analogously to N-{(1S,2R,3S,4R)-4-[2-chloro-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl}-propionamide (Intermediate AA) by replacing cyclopropanecarboxylic acid propionyl chloride with benzyloxy-acetyl chloride.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08193164B2
Source dataset	uspto-grants-2012_06
ORD ID	ord-ae559d32657d48529ec6d75171b4613a
Source note	uspto-grants-2012_06