化工社化工社 化学情報印刷レポート · 研究参考用
HRID 215915作成日：2026年10月25日
Diethyl (3-aminopropyl)phosphonate → Diethyl 3-(4-(1-(2-(Dimethylamino)-6-methoxybenzyl)piperidin-4-ylamino)quinazolin-2-ylamino)propylphosphonate
https://huagongshe.com/reaction/215915
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Diethyl (3-aminopropyl)phosphonate | HCID 78113 | — |
| 反応物 | 2-Chloro-N-(1-(2-(dimethylamino)-6-methoxybenzyl)piperidin-4-yl)quinazolin-4-amine | HCID 58006255 | — |
| 溶媒 | 1-Butanol | HCID 263 | — |
| 生成物 | Diethyl 3-(4-(1-(2-(Dimethylamino)-6-methoxybenzyl)piperidin-4-ylamino)quinazolin-2-ylamino)propylphosphonate | HCID 58006204 | — |
反応手順
Following General Procedure D, Compound 47 (50 mg, 0.12 mmol) and diethyl 3-aminopropylphosphonate (69 mg, 0.36 mmol) in n-BuOH (3 mL) were heated to 117° C. for 24 h with a reflux condenser. The product (Compound 81) was purified by preparative silica gel TLC plate 1000μ using 5% (7N NH3-MeOH) and 95% CH2Cl2 solution as eluent.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08193203B2 |
|---|
| 出典データセット | uspto-grants-2012_06 |
|---|
| ORD ID | ord-ce4843057c1b49bcb9d1098f304d04c1 |
|---|
| 出典メモ | uspto-grants-2012_06 |
|---|
