HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Piperidinecarboxamide → 1-(4-(1-(2-(Dimethylamino)-6-methoxybenzyl)piperidin-4-ylamino)quinazolin-2-yl)piperidine-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Piperidinecarboxamide | HCID 92980 | — |
| Reactant | 2-Chloro-N-(1-(2-(dimethylamino)-6-methoxybenzyl)piperidin-4-yl)quinazolin-4-amine | HCID 58006255 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 1-(4-(1-(2-(Dimethylamino)-6-methoxybenzyl)piperidin-4-ylamino)quinazolin-2-yl)piperidine-3-carboxamide | HCID 58006197 | — |
Reaction Steps
Compound 47 (50 mg, 0.12 mmol) and piperidine-3-carboxamide (45 mg, 0.36 mmol) in 1,4-dioxane (5 mL) were heated to 117° C. for 24 h in a sealed tube. The product (AGN-219171) was purified by basic alumina flash column chromatography using 3% MeOH and 97% CH2Cl2 solution as eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08193203B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-6b7548b5b5d144a5b7d79804b8cda90a |
| Source note | uspto-grants-2012_06 |