HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(1H-pyrrol-1-yl)benzaldehyde → N4-(1-(2-(1H-Pyrrol-1-yl)benzyl)piperidin-4-yl)-N2-(3-(diethylamino)propyl)quinazoline-2,4-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(1H-pyrrol-1-yl)benzaldehyde | HCID 4961259 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | N2-(3-(Dimethylamino)propyl)-N4-(piperidin-4-yl)quinazoline-2,4-diamine | HCID 58006203 | — |
| Reactant | N2-(3-(diethylamino)propyl)-N4-(piperidin-4-yl)quinazoline-2,4-diamine | HCID 67027548 | — |
| Catalyst | Zincchloride | HCID 3007855 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N4-(1-(2-(1H-Pyrrol-1-yl)benzyl)piperidin-4-yl)-N2-(3-(diethylamino)propyl)quinazoline-2,4-diamine | HCID 58006140 | — |
Reaction Steps
A solution of 56 mg (0.155 mmol) N2-(3-(diethylamino)propyl)-N4-(piperidin-4-yl)quinazoline-2,4-diamine (prepared analogously to Compound 129) 2-(1H-pyrrol-1-yl)benzaldehyde (27 mg, 0.157 mmol), NaCNBH3 (10 mg, 0.160 mmol) and ZnCl2 (11 mg, 0.08 mmol) in MeOH (1 ml) was stirred at room temperature overnight to obtain the target compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08193203B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-9ef2bdd6ffff4fbc9f1ded1876e2551b |
| Source note | uspto-grants-2012_06 |