HRID215927

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11875

2-Nitrobenzoyl chloride

C7H4ClNO3

HCID67027548

未命名化合物

PRODUCTS

生成物

结构：CCN(CC)CCCNc1nc(NC2CCN(C(=O)c3ccccc3[N+](=O)[O-])CC2)c2ccccc2n1

HCID67027593

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID222

Ammonia gas

H3N

溶剂HCID6344

Dichloromethane

CH2Cl2

3 次

PROCEDURE

实验过程

A solution of N2-(3-(diethylamino)propyl)-N4-(piperidin-4-yl)quinazoline-2,4-diamine (55 mg, 0.154 mmol) and 2-nitrobenzoyl chloride (57 mg, 0.309 mmol) and TEA (43 ul, 0.309 mmol) in CH2Cl2 was stirred at room temperature for 1 hour. The crude reaction was directly loaded on the silica gel column and isolated the product using 10% NH3 ca. 7 N MeOH in CH2Cl2 and 90% CH2Cl2 solution as eluent to gain a yellow oil.

WORKUP

后处理

customThe crude reaction
customisolated the product

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a3b150312e5f493fb4ad41ab6eba0682
来源数据集: uspto-grants-2012_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08193203B2
来源说明: uspto-grants-2012_06

反应 SMILES

[CH2:1]([N:3]([CH2:25][CH3:26])[CH2:4][CH2:5][CH2:6][NH:7][C:8]1[N:17]=[C:16]([NH:18][CH:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[N:9]=1)[CH3:2].[N+:27]([C:30]1[CH:38]=[CH:37][CH:36]=[CH:35][C:31]=1[C:32](Cl)=[O:33])([O-:29])=[O:28]>C(Cl)Cl.N>[CH2:25]([N:3]([CH2:1][CH3:2])[CH2:4][CH2:5][CH2:6][NH:7][C:8]1[N:17]=[C:16]([NH:18][CH:19]2[CH2:24][CH2:23][N:22]([C:32]([C:31]3[CH:35]=[CH:36][CH:37]=[CH:38][C:30]=3[N+:27]([O-:29])=[O:28])=[O:33])[CH2:21][CH2:20]2)[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[N:9]=1)[CH3:26]