HRID215931

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1cc2nc(Cl)nc(NC3CCN(Cc4c(OCCN(C)C)cccc4N(C)C)CC3)c2cc1OC

HCID58006199

未命名化合物

PRODUCTS

生成物

结构：CCN(CC)CCCNc1nc(NC2CCN(Cc3c(OCCN(C)C)cccc3N(C)C)CC2)c2cc(OC)c(OC)cc2n1

HCID58006127

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID61011

1,3-Propanediamine, N,N-diethyl-

C7H18N2

PROCEDURE

实验过程

Following General Procedure E, Compound 75 (35 mg 0.065 mmol) and 3-(diethylamino)propylamine (30 μL, 019 mmol) were converted into Compound 166.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e88cbfe6a8f34fbc8e1699b855bd1b1e
来源数据集: uspto-grants-2012_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08193203B2
来源说明: uspto-grants-2012_06

反应 SMILES

Cl[C:2]1[N:11]=[C:10]([NH:12][CH:13]2[CH2:18][CH2:17][N:16]([CH2:19][C:20]3[C:25]([O:26][CH2:27][CH2:28][N:29]([CH3:31])[CH3:30])=[CH:24][CH:23]=[CH:22][C:21]=3[N:32]([CH3:34])[CH3:33])[CH2:15][CH2:14]2)[C:9]2[C:4](=[CH:5][C:6]([O:37][CH3:38])=[C:7]([O:35][CH3:36])[CH:8]=2)[N:3]=1>C(N(CC)CCCN)C>[CH2:17]([N:16]([CH2:19][CH3:20])[CH2:15][CH2:14][CH2:13][NH:12][C:2]1[N:11]=[C:10]([NH:12][CH:13]2[CH2:18][CH2:17][N:16]([CH2:19][C:20]3[C:25]([O:26][CH2:27][CH2:28][N:29]([CH3:31])[CH3:30])=[CH:24][CH:23]=[CH:22][C:21]=3[N:32]([CH3:34])[CH3:33])[CH2:15][CH2:14]2)[C:9]2[C:4](=[CH:5][C:6]([O:37][CH3:38])=[C:7]([O:35][CH3:36])[CH:8]=2)[N:3]=1)[CH3:18]