2-Chloro-N-(1-(2-(dimethylamino)-6-(2-(dimethylamino)ethoxy)benzyl)piperidin-4-yl)-6,7-dimethoxyquinazolin-4-amine → N~2~-[3-(Diethylamino)propyl]-N~4~-(1-{2-(dimethylamino)-6-[2-(dimethylamino)ethoxy]benzyl}piperidin-4-yl)-6,7-dimethoxyquinazoline-2,4-diamine
Reaction equation
Cl[C:2]1[N:11]=[C:10]([NH:12][CH:13]2[CH2:18][CH2:17][N:16]([CH2:19][C:20]3[C:25]([O:26][CH2:27][CH2:28][N:29]([CH3:31])[CH3:30])=[CH:24][CH:23]=[CH:22][C:21]=3[N:32]([CH3:34])[CH3:33])[CH2:15][CH2:14]2)[C:9]2[C:4](=[CH:5][C:6]([O:37][CH3:38])=[C:7]([O:35][CH3:36])[CH:8]=2)[N:3]=1>C(N(CC)CCCN)C>[CH2:17]([N:16]([CH2:19][CH3:20])[CH2:15][CH2:14][CH2:13][NH:12][C:2]1[N:11]=[C:10]([NH:12][CH:13]2[CH2:18][CH2:17][N:16]([CH2:19][C:20]3[C:25]([O:26][CH2:27][CH2:28][N:29]([CH3:31])[CH3:30])=[CH:24][CH:23]=[CH:22][C:21]=3[N:32]([CH3:34])[CH3:33])[CH2:15][CH2:14]2)[C:9]2[C:4](=[CH:5][C:6]([O:37][CH3:38])=[C:7]([O:35][CH3:36])[CH:8]=2)[N:3]=1)[CH3:18]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
Following General Procedure E, Compound 75 (35 mg 0.065 mmol) and 3-(diethylamino)propylamine (30 μL, 019 mmol) were converted into Compound 166.
Sources & evidence
- ORD record
- ord-e88cbfe6a8f34fbc8e1699b855bd1b1e
- Source dataset
- uspto-grants-2012_06
- Patent number
- US08193203B2
Reaction notes
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