Triethylamine → HCID 58006260, compound

Participants

Reaction Steps

To a solution of Compound 168 (0.22 g, 0.92 mmol) in THF (10.0 mL) at 0° C. was added 2,4-dichloroquinazoline (0.22 g, 1.10 mmol), followed by Et3N (0.65 mL, 4.60 mmol) and DMAP (catalytic amount), and the reaction was allowed to warm up slowly to ambient temperature and stirred for 18 h, then quenched with 7N NH3 in MeOH. The solvent was removed, and the residue was purified by preparative thin layer chromatography with 7N NH3 in MeOH (2%), hexanes (8%) and CH2Cl2 (90%) to afford the compound EE as a yellow solid.

Provenance & Evidence