HCID 58006117, compound → HCID 58006122, compound

HRID 215933Notes

Reaction equation

HRID 215933 reaction equation
[CH3:1][N:2]([CH3:27])[CH2:3][CH2:4][NH:5][C:6]1[N:15]=[C:14]([NH:16][CH:17]2[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]2)[C:13]2[C:8](=[CH:9][C:10]([O:25][CH3:26])=[C:11]([O:23][CH3:24])[CH:12]=2)[N:7]=1.[CH2:28]([N:30]([CH2:45][CH3:46])[CH2:31][CH2:32][O:33][C:34]1[CH:41]=[CH:40][CH:39]=[C:38]([N:42]([CH3:44])[CH3:43])[C:35]=1[CH:36]=O)[CH3:29]>>[CH2:45]([N:30]([CH2:28][CH3:29])[CH2:31][CH2:32][O:33][C:34]1[CH:41]=[CH:40][CH:39]=[C:38]([N:42]([CH3:43])[CH3:44])[C:35]=1[CH2:36][N:20]1[CH2:21][CH2:22][CH:17]([NH:16][C:14]2[C:13]3[C:8](=[CH:9][C:10]([O:25][CH3:26])=[C:11]([O:23][CH3:24])[CH:12]=3)[N:7]=[C:6]([NH:5][CH2:4][CH2:3][N:2]([CH3:1])[CH3:27])[N:15]=2)[CH2:18][CH2:19]1)[CH3:46]

Participants

3

Reactant 2

HCID 58006117HCID 58006117, compoundHCID 58006270HCID 58006270, compound

Product 1

HCID 58006122HCID 58006122, compound

Procedure

Following General Procedure H, Compound 185 (34.6 mg, 0.093 mmol) and Compound 188 (58.2 mg, 0.22 mmol) were converted into the final product AGN-221250 as a yellow solid.

Sources & evidence

ORD record
ord-6bde26e812de499abbc5573d59fa77eb
Source dataset
uspto-grants-2012_06
Patent number
US08193203B2

Reaction notes

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