HCID 178428769, compound → HCID 178428568, compound

HRID 215956Notes

Reaction equation

HRID 215956 reaction equation
[OH:1][C@@H:2]1[CH2:7][CH2:6][C@H:5]([N:8]2[CH2:12][CH2:11][C:10]3([CH2:17][CH2:16][N:15]([C:18]4[C:23]([CH3:24])=[CH:22][C:21]([N+:25]([O-])=O)=[CH:20][N:19]=4)[CH2:14][CH2:13]3)[C:9]2=[O:28])[CH2:4][CH2:3]1>CO.[Pd]>[NH2:25][C:21]1[CH:22]=[C:23]([CH3:24])[C:18]([N:15]2[CH2:16][CH2:17][C:10]3([C:9](=[O:28])[N:8]([C@H:5]4[CH2:4][CH2:3][C@@H:2]([OH:1])[CH2:7][CH2:6]4)[CH2:12][CH2:11]3)[CH2:13][CH2:14]2)=[N:19][CH:20]=1

Participants

4

Reactant 1

HCID 178428769HCID 178428769, compound

Product 1

HCID 178428568HCID 178428568, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Pd/C (15 mg) was added to a solution of 2-(cis-4-hydroxycyclohexyl)-8-(3-methyl-5-nitropyridin-2-yl)-2,8-diazaspiro[4.5]decan-1-one in methanol (5.0 mL) under an atmosphere of nitrogen. The mixture was stirred under an atmosphere of hydrogen for 2 hrs, and filtered. The filtrate was concentrated to give 8-(5-amino-3-methylpyridin-2-yl)-2-(cis-4-hydroxycyclohexyl)-2,8-diazaspiro[4.5]decan-1-one.

Workup

  1. filtrationfiltered
  2. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-b091e783604a4063929c52c8c5607c5d
Source dataset
uspto-grants-2012_06
Patent number
US08193207B2

Reaction notes

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