Ethyl 2-(2-iminopyridin-1(2H)-yl)acetate hydrobromide → Imidazo[1,2-a]pyridin-2(3H)-one--hydrogen bromide (1/1)

HRID 215965Notes

Reaction equation

HRID 215965 reaction equation
[BrH:1].C([O:4][C:5](=O)[CH2:6][N:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]1=[NH:13])C>C(O)C>[BrH:1].[N:13]1[C:5](=[O:4])[CH2:6][N:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=12

Participants

3

Reactant 1

HCID 68699194Ethyl 2-(2-iminopyridin-1(2H)-yl)acetate hydrobromide

Product 1

HCID 44121307Imidazo[1,2-a]pyridin-2(3H)-one--hydrogen bromide (1/1)

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 9 g (34.4 mmol) of (2-imino-2H-pyridin-1-yl)-acetic acid ethyl ester hydrobromide salt in 200 mL of ethanol is heated at reflux for 18 h. The reaction mixture is then cooled to room temperature and the precipitate is collected. The isolated solid is washed with ethanol to give the desired compound.

Workup

  1. temperatureat reflux for 18 h
  2. customthe precipitate is collected
  3. washThe isolated solid is washed with ethanol

Sources & evidence

ORD record
ord-4312b25132944418ae79d67d6590fecd
Source dataset
uspto-grants-2012_06
Patent number
US08193214B2

Reaction notes

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