反应详情

温度

-78 °C

To a suspension of 137 mg (3.7 mmol) of sodium borohydride in 15 mL of ethanol is added a solution of 500 mg (1.8 mmol) of 3-[1-naphthalen-1-yl-methylidene]-imidazo[1,2-a]pyridin-2-one in 50 mL of methanol, dropwise at −78° C. After stirring for 10 min at −78° C., the reaction mixture is quenched with saturated aqueous ammonium chloride solution at −78° C. The product is extracted with dichloromethane. The organic layer is dried over magnesium sulfate, filtered and concentrated in vacuo to give the desired compound.

1. customdropwise at −78° C
2. customthe reaction mixture is quenched with saturated aqueous ammonium chloride solution at −78° C
3. extractionThe product is extracted with dichloromethane
4. dry with materialThe organic layer is dried over magnesium sulfate
5. filtrationfiltered
6. concentrationconcentrated in vacuo