HuagongsheHuagongshe Chemistry Print Report · For research reference only
1H-Indole-2-carboxylic acid, 1-methyl-5-(phenylmethoxy)-, ethyl ester → Ethyl 5-hydroxy-1-methyl-1H-indole-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1H-Indole-2-carboxylic acid, 1-methyl-5-(phenylmethoxy)-, ethyl ester | HCID 11483680 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl 5-hydroxy-1-methyl-1H-indole-2-carboxylate | HCID 15365972 | 80% |
Reaction Steps
Prepared from ethyl 1-methyl-5-(phenylmethoxy)-1H-indole-2-carboxylate (Monge Vega A, et al., An. Ouim. 72:267) by catalytic hydrogenolysis in ethanol as described in Example 15. Recrystallization from ether gives the product in 80% yield; mp 140°-142° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05424329 |
| Source dataset | uspto-grants-1995_06 |
| ORD ID | ord-ba46a826d6e6487bac0d0fa08f6fa94b |
| Source note | uspto-grants-1995_06 |