反应详情

温度

-78 °C

To a suspension of 121 mg (3.2 mmol) of sodium borohydride in 50 mL of ethanol is added a solution of 624 mg (2.1 mmol) of 3-(4-methyl-benzo[b]thiophen-3-ylmethylene)-imidazo[1,2-a]pyridin-2-one in 50 mL of methanol dropwise at −78° C. After stirring for 15 minutes at −78° C., the reaction mixture is quenched with saturated aqueous ammonium chloride solution at −78° C. The product is extracted with dichloromethane. The organic layer is dried over magnesium sulfate, filtered and concentrated in vacuo to give the desired compound.

1. customthe reaction mixture is quenched with saturated aqueous ammonium chloride solution at −78° C
2. extractionThe product is extracted with dichloromethane
3. dry with materialThe organic layer is dried over magnesium sulfate
4. filtrationfiltered
5. concentrationconcentrated in vacuo