Lawesson's reagent → 3-(4-Methyl-benzo[b]thiophen-3-ylmethyl)-imidazo[1,2-a]pyridine-2-thione

HRID 215973Notes

Reaction equation

[CH3:1][C:2]1[C:10]2[C:9]([CH2:11][CH:12]3[N:16]4[CH:17]=[CH:18][CH:19]=[CH:20][C:15]4=[N:14][C:13]3=O)=[CH:8][S:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.COC1C=CC(P2(=S)SP(=S)(C3C=CC(OC)=CC=3)[S:31]2)=CC=1>C1(C)C=CC=CC=1>[CH3:1][C:2]1[C:10]2[C:9]([CH2:11][CH:12]3[N:16]4[CH:17]=[CH:18][CH:19]=[CH:20][C:15]4=[N:14][C:13]3=[S:31])=[CH:8][S:7][C:6]=2[CH:5]=[CH:4][CH:3]=1

Participants

Conditions

Temperature: 170 °C

Procedure

A suspension of 475 mg (1.6 mmol) of 3-(4-methyl-benzo[b]thiophen-3-ylmethyl)-imidazo[1,2-a]pyridin-2-one and 525 mg (1.3 mmol) of 2,4-bis-(4-methoxyphenyl)-1,3-dithia-2,4-diphosphetane 2,4-disulfide in 20 mL of toluene is heated at 170° C. for 90 minutes under microwave condition. The precipitated solid is collected to give the desired compound.

Workup

customThe precipitated solid is collected

Sources & evidence

ORD record: ord-dffdb1e6d80349beaffc3f0484be36b5
Source dataset: uspto-grants-2012_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08193214B2

Reaction notes

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