Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1-Methyl-N-(9-methyl-9-azabicyclo[3.3.1]nonan-3-yl)-1H-indazole-3-carboxamide | HCID 3510 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 107007-99-8 | HCID 65264 | — |
Reaction Steps
Granisetron (60.0 g) and toluene (12 parts) are charged to a suitable reactor and heated to dissolution. Conc. hydrochloric acid (1.1 eq) is added drop wise while maintaining the temperature at 50 to 60° C. The resulting suspension is distilled at below 80° C. to ⅔ volume and cooled to below 10° C. The solid is collected and dried to provide granisetron hydrochloride (53.6-67 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08193217B2 |
|---|
| Source dataset | uspto-grants-2012_06 |
|---|
| ORD ID | ord-ea0fa1e3490d4219a94332c92fa087fa |
|---|
| Source note | uspto-grants-2012_06 |
|---|
