Dimethyl Sulfoxide → Ethyl 2,2-difluoro-2-(quinolin-6-yl)acetate

HRID 2159817Notes

Reaction equation

HRID 2159817 reaction equation
[CH2:12]([CH3:13])[O:14][C:15]([C:16]([F:17])([F:18])[Br:19])=[O:20].[CH3:27][S:28]([CH3:29])=[O:30].[I:1][c:2]1[cH:3][c:4]2[cH:5][cH:6][cH:7][n:8][c:9]2[cH:10][cH:11]1.[K+:21].[K+:22].[O-:23][C:24]([O-:25])=[O:26]>>[c:2]1([C:16]([C:15]([O:14][CH2:12][CH3:13])=[O:20])([F:17])[F:18])[cH:3][c:4]2[cH:5][cH:6][cH:7][n:8][c:9]2[cH:10][cH:11]1

Participants

6

Reactant 5

HCID 679Dimethyl SulfoxideHCID 813Potassium Cation2×HCID 19660Carbonate IonHCID 69585Ethyl bromodifluoroacetateHCID 203985536-Iodoquinoline

Product 1

HCID 28242385Ethyl 2,2-difluoro-2-(quinolin-6-yl)acetate

Sources & evidence

ORD record
ord-407a1118eab34fe98d1593d5311d29b4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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