5-Chloro-2-(piperidin-4-yloxy)pyridine → 5-[({4-[(5-Chloropyridin-2-yl)oxy]piperidin-1-yl}sulfonyl)methyl]-5-[(3,4,4-trimethyl-2,5-dioxoimidazolidin-1-yl)methyl]imidazolidine-2,4-dione

HRID 2159857Notes

Reaction equation

HRID 2159857 reaction equation
[Cl:24][c:25]1[cH:26][cH:27][c:28]([O:31][CH:32]2[CH2:33][CH2:34][NH:35][CH2:36][CH2:37]2)[n:29][cH:30]1.[O:1]=[C:2]1[NH:3][C:4](=[O:23])[C:5]([CH2:7][N:8]2[C:9](=[O:17])[N:10]([CH3:16])[C:11]([CH3:14])([CH3:15])[C:12]2=[O:13])([CH2:18][S:19](=[O:20])(=[O:21])[Cl:22])[NH:6]1>>[O:1]=[C:2]1[NH:3][C:4](=[O:23])[C:5]([CH2:7][N:8]2[C:9](=[O:17])[N:10]([CH3:16])[C:11]([CH3:14])([CH3:15])[C:12]2=[O:13])([CH2:18][S:19](=[O:20])(=[O:21])[N:35]2[CH2:34][CH2:33][CH:32]([O:31][c:28]3[cH:27][cH:26][c:25]([Cl:24])[cH:30][n:29]3)[CH2:37][CH2:36]2)[NH:6]1

Participants

3

Reactant 2

HCID 112643295-Chloro-2-(piperidin-4-yloxy)pyridineHCID 23133523Racemic {2,5-dioxo-4-[(3,4,4-trimethyl-2,5-dioxoimidazolidin-1-yl)methyl]imidazolidin-4-yl}methanesulfonyl chloride

Product 1

HCID 231334915-[({4-[(5-Chloropyridin-2-yl)oxy]piperidin-1-yl}sulfonyl)methyl]-5-[(3,4,4-trimethyl-2,5-dioxoimidazolidin-1-yl)methyl]imidazolidine-2,4-dione

Sources & evidence

ORD record
ord-75ec5ab0488e490f92e4ea85ce761f8d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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