Piperidine → HCID 86637703, compound

Participants

Reaction Steps

41-[3-[4-(p-chlorophenyl)-5-phenyl-(-[1,2,3]triazol-2-yl)]-3-bromopropane (26 mg, 0.07 mmol) and piperidine (9 mg, 0.10 mmol) were refluxed in ethanol for 1 h in presence of dry sodium carbonate (11 mg, 0.10 mmol). The reaction mixture was then filtrated. The solid was washed with CH2Cl2. The combined filtrates was evaporated in vacuo. The resulting oil was then purified by chromatography on silica gel eluting with EtOAc to afford 1-[3-[4-(p-chlorophenyl)-5-phenyl-(-[1,2,3]triazol-2-yl)propyl]-piperidine (35 mg, 75% yield); 1H NMR (200 MHz, CDCl3, 25° C.) δ=7.53-7.46 (4H, m), 7.39-7.31 (5H, m), 4.52 (2H, t, 3J=7.1 Hz), 2.46-2.39 (6H, m), 2.23 (2H, qt, 3J=7.2 Hz), 1.58 (4H, qt, 3J=5.5 Hz), 1.42 (2H, qt, 3J=5.5 Hz) ppm. ES-MS: m/z=382 (5), 381 (4), 380 (14) [M+●]; 98 (100) [M-283]; 84 (30) [M-297].

Provenance & Evidence