Ethanol → 1-Benzyl-4-[3-(tert-butoxycarbonylamino)-1-hydroxycyclobutan-3-yl]-2-pyrrolidone

HRID 2160184Notes

Reaction equation

HRID 2160184 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[C:9](=[O:33])[CH2:10][CH:11]([C:13]2([NH:25][C:26](=[O:27])[O:28][C:29]([CH3:30])([CH3:31])[CH3:32])[CH2:14][CH:15]([O:17][CH2:18][c:19]3[cH:20][cH:21][cH:22][cH:23][cH:24]3)[CH2:16]2)[CH2:12]1.[CH3:34][CH2:35][OH:36].[OH-:37].[OH-:39].[Pd+2:38]>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[C:9](=[O:33])[CH2:10][CH:11]([C:13]2([NH:25][C:26](=[O:27])[O:28][C:29]([CH3:30])([CH3:31])[CH3:32])[CH2:14][CH:15]([OH:17])[CH2:16]2)[CH2:12]1

Participants

5

Reactant 4

HCID 702EthanolHCID 961Hydroxide2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 184278061-Benzyl-4-[1-benzyloxy-3-(tert-butoxycarbonylamino)cyclobutan-3-yl]-2-pyrrolidone

Product 1

HCID 184278241-Benzyl-4-[3-(tert-butoxycarbonylamino)-1-hydroxycyclobutan-3-yl]-2-pyrrolidone

Sources & evidence

ORD record
ord-7271a8793f0c4408a8e26bf56de6ab44
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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