HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorosuccinimide → 4,5-dichloro-7H-pyrrolo[2,3-d]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorosuccinimide | HCID 31398 | — |
| Reactant | 7H-Pyrrolo(2,3-d)pyrimidine, 4-chloro- | HCID 5356682 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4,5-dichloro-7H-pyrrolo[2,3-d]pyrimidine | HCID 11106092 | — |
Reaction Steps
To a solution of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine (154 mg, 1.0 mmol) in CH2Cl2 (6 mL) was added NCS (134 mg, 1.0 mmol). The reaction mixture was refluxed for 18 hours, filtered, and concentrated under vacuum to give the title compound, which was carried on crude. MS (ES+) [M+H]+=189.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08193202B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-9255f8321f1a499db051fa626ef63d39 |
| Source note | uspto-grants-2012_06 |