HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-Phenylpiperidine-4-carboxylic acid, compound with toluene-p-sulphonic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1-((Tert-butoxy)carbonyl)-4-phenylpiperidine-4-carboxylic acid | HCID 736917 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-Phenylpiperidine-4-carboxylic acid, compound with toluene-p-sulphonic acid | HCID 19259 | 109.3% |
Reaction Steps
1-(tert-Butoxycarbonyl)-4-phenylpiperidine-4-carboxylic acid (1.0 g, 3.3 mmol) was treated with 4 N HCl in dioxane (20 mL) for 2 hours at room temperature. The product was isolated by filtration to provide the title compound (0.74 g, 93%) as a white solid. MS (ES+) [M+H]+=206.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08193202B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-1df7985a55a04ddfa276f21ffbc22a18 |
| Source note | uspto-grants-2012_06 |