4-[[2-(Morpholin-4-ylmethyl)thiophen-3-yl]methyl]morpholine → 7-[4,5-Bis(morpholin-4-ylmethyl)thiophen-2-yl]-4-(2,4-dichloro-5-methoxyanilino)quinoline-3-carbonitrile
Reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([NH:14][c:15]3[c:16]([Cl:24])[cH:17][c:18]([Cl:23])[c:19]([O:21][CH3:22])[cH:20]3)[c:7]([C:12]#[N:13])[cH:8][n:9][c:10]2[cH:11]1.[O:25]1[CH2:26][CH2:27][N:28]([CH2:31][c:32]2[s:33][cH:34][cH:35][c:36]2[CH2:37][N:38]2[CH2:39][CH2:40][O:41][CH2:42][CH2:43]2)[CH2:29][CH2:30]1>>[c:2]1(-[c:34]2[s:33][c:32]([CH2:31][N:28]3[CH2:27][CH2:26][O:25][CH2:30][CH2:29]3)[c:36]([CH2:37][N:38]3[CH2:39][CH2:40][O:41][CH2:42][CH2:43]3)[cH:35]2)[cH:3][cH:4][c:5]2[c:6]([NH:14][c:15]3[c:16]([Cl:24])[cH:17][c:18]([Cl:23])[c:19]([O:21][CH3:22])[cH:20]3)[c:7]([C:12]#[N:13])[cH:8][n:9][c:10]2[cH:11]1Participants
3
Sources & evidence
- ORD record
- ord-9497dd0e89a341dd9422e65c6dd31142
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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