Hydrochloric Acid → 4-methyl-N-(3-(oxazol-5-yl)phenyl)piperidine-4-carboxamide

Participants

Reaction Steps

To a solution of tert-butyl 4-methyl-4-(3-(oxazol-5-yl)phenylcarbamoyl)piperidine-1-carboxylate from step A (77.7 mg, 0.202 mmol) in methanol (3 mL) was added HCl (4.0 N in dioxane, 0.4 mL, 1.6 mmol). The reaction was stirred for 15 hours and then concentrated to dryness to give the title compound as the hydrochloride salt. MS (ES+) [M+H]+=286.2.

Provenance & Evidence