Isopropanol → HCID 57920207, compound

Participants

Reaction Conditions

Reaction Steps

3-(4-benzylpiperidine-4-carboxamido)phenyl dimethylcarbamate (0.140 g, 0.336 mmol) from step B, 4-chloro-5-methyl-7H-pyrrolo[2,3-d]pyrimidine (0.056 g, 0.336 mmol), N,N-diisopropylethylamine (0.175 mL, 1.00 mmol), and isopropanol (5 mL) were combined and heated at 120° C. overnight in a pressure vessel. The reaction was diluted with CH2Cl2, washed with H2O and brine, dried over MgSO4, and concentrated under vacuum. The residue was taken up in hot ethanol/H2O. Upon cooling, the product precipitated out of solution to give the title compound in 81% yield.

Provenance & Evidence