Hydrochloric Acid → HCID 67036860, compound

Participants

Reaction Steps

1-tert-Butyl 4-ethyl 4-(benzyloxymethyl)piperidine-1,4-dicarboxylate from step A (0.500 g, 1.3 mmol) was dissolved in 1 N aq. LiOH (15 mL) and THF (10 mL) and was heated at 50° C. for 24 hours. The reaction mixture was acidified with 1 N HCl and extracted with Et2O. The organic extract was washed with brine, dried over MgSO4, and concentrated under vacuum to afford the title compound (0.3 g, 65%). MS (ES+) [M+H]+=349.

Provenance & Evidence